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Are We Being Misled About Precision Medicine?
By Liz Szabo
Sept. 11, 2018
Facing incurable breast cancer at age 55, MaryAnne DiCanto put her faith in “precision medicine” − in which doctors try to match patients with drugs that target the genetic mutations in their tumors. She underwent repeated biopsies to identify therapies that might help.
“She believed in it wholeheartedly,” said her husband, Scott Primiano of Amityville, N.Y.
Around this point in the typical news report, readers would learn how Ms. DiCanto, mother to a blended family of five, took a chance on an experimental drug that no one expected to work.
She would be the scrappy protagonist who beat the odds − allowing us to celebrate the triumph of modern science and worry a bit less about our own mortality.
But there’s a problem with talking about precision medicine for cancer this way: It misleads the public.
Ms. DiCanto’s high hopes, she died last year at age 59. According to her husband, she had benefited from standard cancer treatments, but none of the targeted therapies recommended through genetic testing extended her life.
Doctors and hospitals love to talk about the patients they’ve saved with precision medicine, and reporters love to write about them. But the people who die still vastly outnumber the rare successes.
“There are very few instances in which we can look at a genomic test and pick a drug off the shelf and say, ‘That will work,’” said Dr. Nikhil Wagle, a cancer specialist at Dana-Farber Cancer Institute in Boston who helped develop precision-medicine tests. “That’s our goal in the long run, but in 2018 we’re not there yet.”
Mr. Primiano said: “You think it’s going to be more precise, like a laser versus a shotgun. But it’s still a shotgun.”
(Disponível em: https://www.nytimes.com/2018/09/11/opinion/cancer-genetic-testing-precision-medicine.html)
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