TEXTO II
F.D.A. Approves First Drug Designed to Prevent Migraines
“Robin Overlock experienced frequent, debilitating migraines that would last days. After participating ∈a clinical trial for a new drug designed to prevent migraines, she says she now has only occasional headaches. Credit: Cheryl Senter for The New York Times”
“The first medicine designed to prevent migraines was approved by the Food and Drug Administration on Thursday, ushering ∈ what many experts believe will be a new era ∈ treatment for people who suffer the most severe form of these headaches.
The drug, Aimovig, made by Amgen and Novartis, is a monthly injection with a device similar to an insulin pen. The list price will be $6,900 a year, and Amgen said the drug will be available to patients within a week.
Aimovig blocks a protein fragment, CGRP, which instigates and perpetuates migraines. Three other companies — Lilly, Teva and Alder — have similar medicines ∈ the final stages of study or awaiting F.D.A. approval.
“The drugs will have a huge impact,” said Dr. Amaal Starling, a neurologist and migraine specialist at the Mayo Clinic ∈Phoenix. “This is really an amazing time for my patient population and for general neurologists treating patients with migraine.””
(Adapted from: https://www.nytimes.com/2018/05/17/health/migraines-prevention-drug)
Which alternative below has the correct synonym of the verb “instigates” (3rd paragraph)?
