Angelina Jolie underwent a preventive double mastectomy after doctors estimated she had an 87% chance of developing breast cancer. How was that figure calculated and how does it differ from other women's risk of getting the disease? Jolie's chances of developing breast cancer were so high because she inherited a mutated BRCA 1 gene from her mother, Marcheline Bertrand, who died of ovarian cancer at the age of 56. The BRCA1 is present ∈ everyone but only mutates ∈ one ∈1,000 people. Anyone with the mutation has a 50-80% chance of developing breast cancer. But Jolie's risk figure was calculated to be even higher because of other factors, including family history.
But what are the chances of getting breast cancer if you don't have a mutated gene? It is already "the top cancer ∈ women both ∈ the developed and the developing world", according to the World Health Organization - and ∈ many countries, it's becoming more common. This is partly explained by the fact that people are living longer and cancer is generally a disease that affects people ∈ later life.
In the UK, the chance of developing breast cancer before the age of 30 is roughly 0.05% (one ∈2,000). It goes up to 2% (one ∈50) before the age of 50 and 7.7% (one ∈13) before the age of 70. However, it is after the age of 70 that the risk is highest. But increasing longevity isn't the only reason for the high incidence of breast cancer. "There is an increase ∈ rates ∈ younger women and it's for a number of reasons. We know that women's lifestyles are changing and being overweight and drinking a lot of alcohol is linked to breast cancer risk," says Dr Kat Arney, a senior science manager at Cancer Research UK. Changes ∈ reproductive habits are also a factor. According to Cancer Research UK, the relative risk of developing breast cancer is estimated to increase by 3% for each year an adult woman delays becoming a mother.
Women who breastfeed also reduce their risk. It's estimated that risk is reduced by 4% for every 12 months of breastfeeding. This may explain why women ∈ richer countries have a higher risk of breast cancer. African women are four times less likely to get the disease because they have children at a younger age, have more of them and breastfeed them for longer.
On the other hand, recovery rates are higher ∈ developed countries. "Breast cancer survival rates [range] from 80% or over ∈North America, Sweden and Japan to around 60% ∈ middle-income countries and below 40% ∈ low-income countries," according the WHO. But with the number of cases of breast cancer rising ∈ the UK, and ∈ many other countries, how many women are taking the dramatic decision that Angelina Jolie was faced with - to have a mastectomy? The latest figures show that 18,000 operations were carried out ∈England ∈2010/11. There are no official figures on how many of those were preventive but the figure is estimated to be between 5-10%.
(Source: Adapted from http://www.bbc.co.uk/news/magazine)
According to the information ∈ the text, researchers at Cancer Research UK say:
