Questão 57

What is this text about?

Lost

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translation: Researchers discover translator gene may play a role

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disease

When researchers and clinicians investigate the genome's relation to disease, they have traditionally focused on mutations

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the code for proteins. But now researchers at Western University have shown that the genes encoding tRNAs can also have mutations that cause the code to be misread, and

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greater numbers than previously thought.

Think of it like a translator app on your phone -- if it has errors

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its software, the output is going to be all wrong, even if the original text is correct.

"This actually changes the way we think about the genetic code," said lead author Mathew Berg, a PhD Candidate at Western's Schulich School of Medicine & Dentistry. "We have shown that variation

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has the potential to lead to a protein being made improperly, which can lead to misfolding and malfunction of the protein."

The research team, led by Schulich Medicine & Dentistry Professors Christopher Brandl, Robert Hegele and Patrick O'Donoghue, say this is significant because many human diseases like Alzheimer's disease and diseases of the heart muscle are linked to misfolded proteins.

https://www.sciencedaily.com/releases/2019/08/190813130422.htm